Erratum to: Potassium Supplements and Potassium-Sparing Diuretics

Potassium-Sparing Diuretics in Hypertension

Diuretics in the treatment of hypertension. Part 2: loop diuretics and potassium-sparing agents.

INTRODUCTION Diuretics enhance the renal excretion of Na(+) and water due to a direct action at different tubular sites of the nephron where solute re-absorption occurs. AREAS COVERED This paper focuses on the mechanism of action, pharmacodynamics, antihypertensive effects, adverse effects, interactions and contraindications of loop diuretics and potassium-sparing agents (including mineraloco...

Diuretics, potassium, and ventricular ectopy.

I tion alone accounted for this and whether the reduction would have been greater had the diuretics not caused a ‘‘backlash’’ of cardiotoxicty. Certainly, the introduction of orally available thiazide diuretics in 1957–8 revn November 1985, we reviewed the then current status of experimental and clinical evidence and opinion on diuretic-associated hypokalemia with particular attention to its po...

Effect of potassium-sparing diuretics on the renin-angiotensin-aldosterone system and potassium retention in heart failure.

The renin-angiotensin-aldosterone system and electrolyte levels in 11 patients with heart failure controlled on digoxin and frusemide were investigated after separate periods of Slow K, spironolactone, and amiloride therapy. When spironolactone or amiloride replaced Slow K, distinct parallel increments in the levels of renin, angiotensin II, and aldosterone resulted. Though plasma potassium was...

In vitro antistreptococcal activity of the potassium-sparing diuretics amiloride and triamterene.

The ionophore antimicrobial agents provide evidence that perturbations of the electrolyte balance of bacterial cells exert a growth-inhibitory activity. Several drugs acting on animal cell membranes have also been shown to be active on bacterial cells. In this paper, we report preliminary susceptibility studies showing that the class of potassium-sparing diuretics acting directly on monovalent ...